Nathan Drake will absolutely not make an appearance in this year's standalone Uncharted experience The Lost Legacy, Naughty Dog has confirmed to PlayStation Blog.
"We entertained a few possible ideas around including Nate as a secondary character," Lost Legacy writer Josh Scherr explained. "But everything we did felt superfluous because we tied it all up with Uncharted 4."
Game director Kurt Margenau added: "We’re not going to touch on Nathan Drake in this, at all."
Instead the story will focus on characters Chloe and Nadine, set six to twelve months after the events of Uncharted 4. The pair must work together to obtain the Tusk of Ganesha from a mysterious warlord named Asav.
Source: PlayStation Blog