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Capcom has announced the minimum and recommended system requirements for its PC version of Resident Evil 5.
Minimum Requirements:
OS: Windows XP
CPU: Intel PentiumD Processor
AMD Athlon64 X2
RAM: Windows Vista (1GB)
Windows XP (512MB)
HDD: 8.0GB or more
Graphics: VRAM (256MB)
DirectX9.0c/Shader 3.0
NVIDIA GeForce 6800 series
ATI Radeon HD 2400 Pro
Sound: DirectSound Compatible (DirectX9.0c or higher)
Recommended Requirements:
OS: Windows Vista
CPU: Intel Core2Quad Processor or better
AMD Phenom X4 or better
RAM: Windows Vista (2GB or more)
Windows XP (1GB or more)
HDD: 8.0GB or more
Graphics: VRAM (512 or more)
NVIDIA GeForce 9800 series or better
ATI Radeon HD 4800 series or better
Sound: DirectSound Compatible (DirectX9.0c or higher)
Resident Evil 5 is scheduled for release on PC on September 18. In addition to trusting the specs above you can also download the benchmark tool and judge how well your current rig holds up.