The First Descendant how to get Python and best build

✓ At a glance

• Python is an Ultimate tier submachine gun that you can get by researching it with Anais in Albion.
• You will need to research Polymer Syncytium, Synthetic Fiber, Nano Tube, and get the Python Blueprint to be able to research the weapon.
• Python’s special ability lowers defences and resistances of enemies with Weak Spots, making it excellent for shredding bosses.

Most end-game weapons in The First Descendant can serve as both good general options, as well as filling a specialist niche. Python is a good example, being an Ultimate submachine gun that excels at taking down Colossi by targeting their weak spots. We’ll explain how you can get your hands on one and give insight how to build it.

How to research Python

Python is an Ultimate weapon that needs to be researched in Albion with Anais after reaching Mastery Rank 10. You will need to gather several rare components to begin the research, many of which will need to be researched themselves. 

In addition to researching Python’s relevant components, you will have to acquire the Python Blueprint, which only drops for Amorphous Materials. So ironically, to kill bosses with this SMG, you’ll need to defeat them first to get the material you need. This is what you’ll need to craft the weapon:

Component	How to get
Python Polymer Syncytium	Research with blueprint
Python Synthetic Fiber	Research with blueprint
Python Nano Tube	Research with blueprint
Python Blueprint	Random drop
100,000 Gold	N/A

As we can see, three components need to be researched beforehand, which means spending more time, gold, and materials to get them. All in all, it will take a total of 250,000 gold and 8 hours of research time to get the Python, as well as all the resources you need to grind for.

While preparing everything for crafting, it’s a good idea to try and focus on obtaining components one by one and planning farming routes. It will take a while, so be patient and try to get everything you need in order, then move on to the next component.

How to get Python Blueprint

The Blueprint is the component that could take the most randomness to drop. The best way to get it is through a Void boss battle, but there are also a few missions that offer a small drop chance:

• Intercept Battle (Normal): Dead Bride (Amorphous Material Pattern: 025)
• Abyssal Void Fusion Reactor mission in Vespers – Ruins (Hard)
• Abyssal Void Fusion Reactor mission in Fortress – Defense Line (Hard)
• Abyssal Void Fusion Reactor mission in Sterile Land – Repository (Hard)

Everything you need to gather to craft this component. Captured by VideoGamer

You can pick between fighting bosses or farming missions to get the blueprint. Captured by VideoGamer

Previous

Next

1 of 2

Previous

Next

How to get Python Polymer Syncytium

You will need to get the Blueprint for this component, as well as several other materials. Then, it will take 2 hours to complete the research. Here’s everything that you’ll need:

Resource	Amount needed
Hardener	97
Nanopolymers	91
Crystal Biogel	11
Python Polymer Syncytium Blueprint	1
Gold	50,000

There are a couple of ways to get your hands on the Blueprint:

• Intercept Battle (Normal): Devourer (Amorphous Material Pattern: 029)
• Intercept Battle (Normal): Swamp Walker (Amorphous Material Pattern: 044-Mutant AA)
• Intercept Battle (Normal): Swamp Walker (Amorphous Material Pattern: 044)
• Abyssal Void Fusion Reactor mission in Kingston – Grand Square (Hard)
• Abyssal Void Fusion Reactor mission in Agna Desert – Vermillion Waste (Hard)

It takes a lot of farming to get these materials. Captured by VideoGamer

You can only get this blueprint by defeating bosses. Captured by VideoGamer

Previous

Next

1 of 2

Previous

Next

How to get Python Synthetic Fiber

Just like before, you’ll need to get the Blueprint for this piece, then combine it with other necessary materials. It will then take another 2 hours to research it. Here’s what you need to get:

Resource	Amount needed
Silicon	108
Flectorite	73
Positive Ion Particle	10
Python Synthetic Fiber Blueprint	1
Gold	50,000

You’ll need to face down bosses to get the Blueprint for this component:

• Intercept Battle (Normal): Grave Walker (Amorphous Material Pattern: 005)
• Intercept Battle (Normal): Stunning Beauty (Amorphous Material Pattern: 009)
• Intercept Battle (Hard): Swamp Walker (Amorphous Material Pattern: 096)
• Intercept Battle (Hard): Obstructer (Amorphous Material Pattern: 105)

This component could easily take you the longest to craft. Captured by VideoGamer

You have only a few choices to farm the Nano Tube blueprint. Captured by VideoGamer

Previous

Next

1 of 2

Previous

Next

How to get Python Nano Tube

The third and final component that needs to be researched will also require a Blueprint first. Then, combine it with the other materials on the list below and wait for 2 hours for the research to complete. This is everything you’ll need to grind for:

Resource	Amount needed
Monad Shard	62
Ceramic Composite	102
Conductive Metallic Foil	8
Python Nano Tube Blueprint	1
Gold	50,000

There are a few ways to get the necessary Blueprint:

• Intercept Battle (Normal): Pyromaniac (Amorphous Material Pattern: 039)
• Intercept Battle (Hard): Executioner (Amorphous Material Pattern: 059)
• Void Fusion Reactor mission in Sterile Land – Repository (Normal)
• Abyssal Void Fusion Reactor mission in White-night Gulch – Hatchery (Hard)

What does the Python Ultimate SMG do?

Python is an Ultimate submachine gun that uses general (white) rounds and excels at taking down weak spots on bosses. In addition, it has an effect that lowers the enemy’s defences and Toxin resistance. However, it suffers from low range and high recoil, so it’s a good idea to offset that with modules. Also, the gun has a great fire rate and decent damage, which is even better if it can stack its Prey unique ability.

Speaking of which, let’s discuss the bread and butter of this gun, its special ability called Prey. Upon hitting a Weak Point on an enemy, it inflicts the following Prey debuff stack:

Stat	Effect
Duration	1 second
Max Stacks	20
Non-Attribute Resistance	-2%
Toxin Resistance	-1%
Non-Attribute Resistance per Stack	-3.6%
Toxin Resistance per Stack	-1.3%

As we can see, you can stack this up to 20, and with Python’s fire rate, that can be done pretty quickly. That will make shredding bosses a breeze with this weapon once you’ve built up the stacks. 

Best build for Python

Python is best deployed when fighting Colossus bosses that have Weak Spots to leverage Prey. The Modules you use should be aimed at increasing its ATK value, expanding the magazine size, and lowering Recoil.

After that, you should look to leverage the gun’s Toxin debuff by adding Toxin damage, increasing fire rate, and even mods that increase Weak Point damage. To that end, look for some of the following Modules:

Module	Effect
Action and Reaction	Firearm ATK +15%, Recoil +5%
Consume Magazines	Reload Time Modifier +25%, Weak Point Damage +2%
Expand Weapon Charge	Rounds per Magazine +49%
Fire Rate UP	Fire Rate +25%
Fixed Shot	Recoil -30%, Weak Point Damage +2%
Have Aiming	Weak Point Damage +40%, Accuracy -20%
Maximize Weight Balance	Rounds per Magazine +30%, Weak Point Damage +2%
Mental Focus	Fire Rate -10%. When firing a firearm, Firearm ATK +1% for 2s
Pinpoint Shot	Firearm ATK +26%, Weak Point Damage +2%
Poison Priority	Toxic ATK +50%, Reload Time Modifier -30%
Rifling Reinforcement	Firearm ATK +32%
Toxic Enhancement	Adds Toxic ATK equal to 30% of Firearm ATK
Vibration Absorption	Recoil -45%
Weak Point Aiming	Accuracy +30%, Weak Point Damage +2%
Weak Point Sight	Weak Point Damage +35%

Best Descendants for Python

The most obvious Descendant to use Python with is Freyna. She specializes in dealing Toxic damage through DoTs, which pairs perfectly with the gun’s Prey debuff. Lower the boss’ resistances and defences and apply her DoTs, then watch the health melt away.

Alternatively, you could try using it with Gley. The Python’s high rate of fire pairs well with Gley’s Massacre ability, transferring the fire rate bonus between the two. With that said, you can use Python with any Descendant to take down bosses, but the two we mentioned above will provide the most synergy with the gun’s capabilities.