Alyx Vance, Half-Life 2
The thing with Half-Life 2's Alyx was she was insanely realistic. So realistic, in fact, that as Gordon Freeman's relationship with her grew she became less like a video game companion and more like a real-life companion. One who, you know, if you had a shave and maybe splashed on some Old Spice, might, you know… not find you insta-vom repulsive. Some have taken this video game crush too far, doing unhealthy things with blow-up dolls, make-up, and head bands.