4. Tifa Lockhart – Final Fantasy VII
Tifa Lockhart, Tetsuya Nomura's confident, no nonsense Final Fantasy VII vixen, was a perfect foil for Cloud's emo musings. She wouldn't suffer his moping, and often chastised him for being such a grump. As adept with her fists as she was with her feet, Tifa proved immensely popular with series fans. Really, she's a pin-up girl for the gaming generation, and the role-playing genre's Lara Croft. If there is to be a Final Fantasy VII remake, or a new Final Fantasy game set in VII's mechanical world, Tifa's re-imagining would be of more interest than Cloud's or indeed Sephiroth's.
3. Dogmeat - Fallout Series
"You see one mean-looking dog" read the in-game description in the original Fallout. They weren't kidding, either: Dogmeat was so much more than just man's best friend - he was a furry little killing machine who would frequently save the player's life. In Fallout 1 you found him in Junktown, ferociously barking at strangers near the spot where his last master died. If you then put on a leather jacket or simply gave him some food, he'd be your buddy for life. Gamers went to great lengths to protect their little pooch, way beyond his intended lifespan, to the extent that there are still strategy guides online that explain how to keep him safe during Fallout's dangerous endgame. The mutt has since gone on to appear in Fallouts 2 and 3, but it's arguably his first appearance that remains his defining role. He's a dog who knocks bandits off their feet and then bites their crotch until they die. What's not to love?