With such a massive amount of gamers playing GTA 4 there were bound to be some problems reported, the first being a freezing issue with the PS3 version of the game.
Numerous forum posters are reporting the game has frozen on them during a cut scene early on in the game, with technical support suggesting those experiencing problems erase the install files and the game save and start over. This fix, according to reports, does appear to remedy the problem.
There have also been reports of freezing in the Xbox 360 game, but with no hard drive install it could be that the problems there are just random occurrences.
We've had the Xbox 360 version on for well over 40 hours and had no problems and we're also crash-free after several hours with the PS3 game.