But pair's "lack of moral compass" might put off Hollywood studios.
Sam and Max's "lack of a functioning moral compass might make them a long shot to drive a major studio production," but the cartoon cop duo "would make a great movie", creator Steve Purcell believes.
Talking to VideoGamer.com about his role in the development of recent Pixar tie-in Brave: The Video Game, Purcell said that "Sam & Max have proved themselves remarkably resilient to adaptation".
"They always manage to maintain the integrity of their lunacy no matter the medium. I think they would make a great movie."
Purcell debuted the characters in a comic book in the 1980s, before releasing classic PC point & click Sam & Max: Hit The Road in 1993. The pair later spawned a TV series, before Purcell moved to Pixar in the early noughties.
So given his big screen experience, why hasn't Purcell attempted to take Sam & Max to Hollywood?
"I've just tended to keep Sam & Max separate from my work at Pixar so there's never any confusion about it," he continued.
"I think Sam & Max's lack of a functioning moral compass might make them a long shot to drive a major studio production. Though I'm certainly not opposed to giving it a shot."