Over 1,000 fans queued up to get their hands on the game.
Diablo 3's midnight launch event at HMV Oxford Street was the entertainment retailer's biggest launch to date, games boss Ewan Pinder has revealed.
At least 1,000 gamers are said to have queued at the London store, some even dressed in costume.
"The launch of Diablo III has to rank alongside World of Warcraft as our biggest ever official product launch at an HMV store," said Pinder.
"We estimate that at least 1,000 fans queued patiently and with good humour for many hours – including in the rain – with the first diehards arriving as early as Friday night. Only games have the power and the passion to deliver this kind of result and level of engagement.
"I have to congratulate the guys at Activision Blizzard on such a spectacular and epic launch and on staging some of the best retail theatre I've ever seen. Big thanks also to our team at HMV and at the store for their fantastic support and, of course, not least to our wonderful customers who came along in such large numbers and helped to make this such a memorable, landmark event."