Origami Killer – Heavy Rain
Who is the Origami Killer? I know, but I'm not going to say because that would spoil the surprise. Just know that anyone who kidnaps kids and then drowns them in rainwater is one messed up individual. More so than any other game, Heavy Rain allows players to see into the minds of each of its protagonists, making the eventual reveal something very special indeed. It's one of the greatest 'who dunits' in video game history.
James Lynch – Kane and Lynch
Paranoid, schizophrenic, and completely out of his mind, James Lynch is one of video games most illustrious nut jobs. Doctors were obviously aware of this too, as Lynch is required to take prescribed medication to keep his raging psychotic outbursts in check. If it wasn't for his slightly more rational sidekick Kane, there's no telling what kind of trouble Lynch would find himself in. Despite his somewhat unstable nature, Lynch is a top guy to have on side in the midst of a violent and bloody struggle with a heavily armed mercenary group. Kane's a lucky guy.